Evasion of innate immunity by vaccinia virus

被引：64

作者：

Haga, IR ^{[1
]}

Bowie, AG ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland

来源：

PARASITOLOGY | 2005年 / 130卷

关键词：

vaccinia virus; immune evasion; signal transduction; nuclear factor kappa B; toll-like receptors;

D O I：

10.1017/S0031182005008127

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Vaccinia virus, a member of the Poxviridae, expresses many proteins involved in immune evasion. In this review, we present a brief characterisation of the virus and its effects on host cells and discuss representative secreted and intracellular proteins expressed by vaccinia virus that are involved in modulation of innate immunity. These proteins target different aspects of the innate response by binding cytokines and interferons, inhibiting cytokine synthesis, opposing apoptosis or interfering with different signalling pathways, including those triggered by interferons and toll-like receptors.

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收藏

页码：S11 / S25

页数：15

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