Acidocalcisome:: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites

被引:103
作者
Docampo, R [1 ]
Moreno, SNJ [1 ]
机构
[1] Univ Illinois, Coll Vet Med, Dept Pathobiol, Mol Parasitol Lab, Urbana, IL 61802 USA
来源
PARASITOLOGY TODAY | 1999年 / 15卷 / 11期
关键词
D O I
10.1016/S0169-4758(99)01531-8
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Acidocalcisomes are novel acidic Ca2+ storage organelles found in trypanosomatids and apicomplexan parasites, abundant in the intracellular stages of these parasites, and characterized by their high electron density, and high content of phosphorus, Ca2+, Mg2+, Na+ and Zn2+. A number of energy-utilizing pumps and exchangers have been found in these organelles, which underlines their importance in the homeostasis of different elements, as discussed here by Roberto Docampo and Silvia Moreno.
引用
收藏
页码:443 / 448
页数:6
相关论文
共 54 条
[41]   LOCALIZATION OF AZITHROMYCIN IN TOXOPLASMA GONDII-INFECTED CELLS [J].
SCHWAB, JC ;
CAO, Y ;
SLOWIK, MR ;
JOINER, KA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) :1620-1627
[42]   CA2+ STORAGE IN TRYPANOSOMA-BRUCEI - THE INFLUENCE OF CYTOPLASMIC PH AND IMPORTANCE OF VACUOLAR ACIDITY [J].
SCOTT, DA ;
MORENO, SNJ ;
DOCAMPO, R .
BIOCHEMICAL JOURNAL, 1995, 310 :789-794
[43]   Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi [J].
Scott, DA ;
de Souza, W ;
Benchimol, M ;
Zhong, L ;
Lu, HG ;
Moreno, SNJ ;
Docampo, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (34) :22151-22158
[44]   In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi [J].
Scott, DA ;
Docampo, R ;
Dvorak, JA ;
Shi, SL ;
Leapman, RD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :28020-28029
[45]   LYSOSOMOTROPIC AMINES MODULATE NEUTROPHIL CALCIUM HOMEOSTASIS [J].
STYRT, B ;
KLEMPNER, MS .
JOURNAL OF CELLULAR PHYSIOLOGY, 1988, 135 (02) :309-316
[46]   H+-DEPENDENT CALCIUM-UPTAKE INTO AN IP3-SENSITIVE CALCIUM POOL FROM RAT PAROTID-GLAND [J].
THEVENOD, F ;
SCHULZ, I .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (04) :G429-G440
[47]  
URBINA JA, IN PRESS J BIOL CHEM
[48]   The role of a H+-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes [J].
Vanderheyden, N ;
Benaim, G ;
Docampo, R .
BIOCHEMICAL JOURNAL, 1996, 318 :103-109
[49]   Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei [J].
Vercesi, AE ;
Docampo, R .
BIOCHEMICAL JOURNAL, 1996, 315 :265-270
[50]  
Vercesi AE, 1997, BIOCHEM J, V328, P479