Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

被引:161
作者
Kidani, Yoko [1 ,2 ]
Bensinger, Steven J. [1 ,2 ,3 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
关键词
liver X receptor; peroxisome proliferator-activated receptor; lipids; lupus; immunity; INFLAMMATORY RESPONSE GENES; PPAR-GAMMA AGONISTS; HELPER T-CELLS; NUCLEAR RECEPTOR; LXR-ALPHA; ACCELERATES ATHEROSCLEROSIS; NEUTROPHIL HOMEOSTASIS; SIGNALING PATHWAY; RXR HETERODIMERS; APOPTOTIC CELLS;
D O I
10.1111/j.1600-065X.2012.01153.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lipid metabolism has emerged as an important modulator of innate and adaptive immune cell fate and function. The lipid-activated transcription factors peroxisome proliferator-activated receptor (PPAR) alpha, beta/delta, gamma and liver X receptor (LXR) are members of the nuclear receptor superfamily that have a well-defined role in regulating lipid homeostasis and metabolic diseases. Accumulated evidence over the last decade indicates that PPAR and LXR signaling also influence multiple facets of inflammation and immunity, thereby providing important crosstalk between metabolism and immune system. Herein, we provide a brief introduction to LXR and PPAR biology and review recent discoveries highlighting the importance of PPAR and LXR signaling in the modulation of normal and pathologic states of immunity. We also examine advances in our mechanistic understanding of how nuclear receptors impact immune system function and homeostasis. Finally, we discuss whether LXRs and PPARs could be pharmacologically manipulated to provide novel therapeutic approaches for modulation of the immune system under pathologic inflammation or in the context of allergic and autoimmune disease.
引用
收藏
页码:72 / 83
页数:12
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