Bafilomycin A(1) and intracellular multiplication of Legionella pneumophila

被引：8

作者：

Cattani, L

Goldoni, P

Pastoris, MC

Sinibaldi, L

Orsi, N

机构：

[1] UNIV ROMA LA SAPIENZA,FAC MED & CHIRURG,IST MICROBIOL,I-00185 ROME,ITALY

[2] IST SUPER SANITA,BATTERIOL & MICOL MED LAB,I-00161 ROME,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 01期

关键词：

D O I：

10.1128/AAC.41.1.212

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multiplication of Legionella pneumophila in HeLa cells was found to be inhibited by noncytotoxic concentrations of bafilomycin A(1), with blockage of bacterial growth at a concentration 15.6 nM. The inhibiting action was evident only when the antibiotic was present during the initial phase of intracellular multiplication, i.e., during the formation of the phagosome, whereas the addition of the drug did not affect microorganisms already actively multiplying within the phagosome.

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页码：212 / 214

页数：3

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