A versatile method for Suzuki cross-coupling reactions of nitrogen heterocycles

被引：357

作者：

Kudo, N ^{[1
]}

Perseghini, M ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 08期

关键词：

cross-coupling; heterocycles; homogeneous catalysis; nitrogen; palladium;

D O I：

10.1002/anie.200503479

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A wide-ranging study of Suzuki reactions which use nitrogen-containing heterocycles is described (see scheme; dba = dibenzylideneacetone, Cy = cyclohexyl). This method is highly versatile (a single procedure was used for all substrates, including boronate esters and trifluoroborates), compatible with a variety of unprotected functionalities (e.g., NH2-and OH-substituted substrates), and efficient even with unactivated aryl chlorides. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1282 / 1284

页数：3

共 18 条

[1] Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides [J].