Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions

被引：139

作者：

Schwiebert, LA ^{[1
]}

Beck, LA ^{[1
]}

Stellato, C ^{[1
]}

Bickel, CA ^{[1
]}

Bochner, BS ^{[1
]}

Schleimer, RP ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED,JOHNS HOPKINS ASTHMA & ALLERGY CTR, DIV CLIN IMMUNOL,DEPT MED, BALTIMORE, MD 21224 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1996年 / 97卷 / 01期

关键词：

COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; LEUKOCYTE ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL-CELLS; ANTI-INFLAMMATORY STEROIDS; HUMAN MAST-CELLS; HUMAN EOSINOPHILS; T-CELLS; BRONCHOALVEOLAR LAVAGE; AIRWAY INFLAMMATION;

D O I：

10.1016/S0091-6749(96)80214-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We believe that there are the following four classes of glucocorticoid- sensitive cytokines that are involved in cell recruitment: (1) those that activate endothelium nonspecifically; (2) those that activate endothelium specifically; (3) those that activate, prime, and prolong the survival of eosinophils; and (4) those that stimulate movement of cells up into the epithelium. Glucocorticoids inhibit the generation of these cytokines and thereby prevent several different aspects of inflamation, including the activation and recruitment of inflammatory cells (eosinophils, basophils, and lymphocytes) and the release of inflammatory mediators. We believe such pleiotropic actions account for the efficacy and widespread use of glucocorticoids in the treatment of asthma.

引用

页码：143 / 152

页数：10

共 105 条

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