The effect of multifunctionality on the rate of evolution in yeast

被引：48

作者：

Salathé, M ^{[1
]}

Ackermann, M ^{[1
]}

Bonhoeffer, S ^{[1
]}

机构：

[1] ETH, Inst Integrat Biol, CH-8092 Zurich, Switzerland

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2006年 / 23卷 / 04期

关键词：

pleiotropy; dN/dS; evolutionary genomics; rate of evolution;

D O I：

10.1093/molbev/msj086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multifunctional genes are expected to evolve at lower rates because mutations in such genes that improve one function might often have deleterious effects on other functions. Here we tested for an association between multifunctionality and evolutionary rates in genes of Saccharomyces cerevisiae, and we find a highly significant negative correlation between the number of biological processes in which a gene is involved in and its rate of evolution. However, the magnitude of this effect is small, and the results do not support the notion that multifunctionality limits a gene's rate of evolution.

引用

页码：721 / 722

页数：2

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