Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes

被引：19

作者：

Hernández, JM ^{[1
]}

Giner, P ^{[1
]}

Hernández-Yago, J ^{[1
]}

机构：

[1] Fdn Valenciana Invest Biomed, Inst Invest Citol, Valencia 46010, Spain

来源：

GENE | 1999年 / 239卷 / 02期

关键词：

human Tom20; mitochondria; mitochondrial protein receptor; molecular evolution; nuclear gene;

D O I：

10.1016/S0378-1119(99)00409-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The structure of the human gene encoding the mitochondrial outer membrane receptor Tom20 has been determined from overlapping clones obtained using PCR-based techniques. The 20 kb human Tom20 gene (hTom20) consists of five exons separated by four introns. The 5' flanking region presents features common with other nuclear genes encoding mitochondrial proteins. Comparison with its homologs and putative homologs in other species has revealed common features in their TPR motifs and other relevant protein domains. Aspects concerning evolutionary origins of the family of processed pseudogenes of hTom20 are also discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：283 / 291

页数：9

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