Capsule endoscopy findings in patients with suspected Crohn's disease and biochemical markers of inflammation

Background. Because it provides a direct view of superficial lesions in the small bowel, capsule endoscopy is a promising diagnostic toot for studying patients with suspected Crohn's disease undetected by conventional modalities. Aim. To assess the role of capsule endoscopy in the diagnosis of patients with Suspected Crohn's disease. Patients and methods. Thirty-eight patients (16 males, mean age 46.2 years) with suspected Crohn's disease but negative at conventional imaging were examined using capsule endoscopy. They were divided into 2 groups: 12 patients with ongoing symptoms (Group 1), and 26 with ongoing symptoms and biochemical markers of inflammation (Group 2). Capsule endoscopy findings were classified as diagnostic (multiple erosions/ulcerations), suspicious (<= 3 erosions/ulcerations), non-specific and normal. Results. Capsule endoscopy findings were diagnostic for Crohn's disease in 13 (34.2%) patients. suspicious in 2 (5.3%), non-specific in 4 (10.5%) and normal in 19 (50%), with an overall detection rate of 39.5%. The yield of positive findings was 8.3% in Group 1 and 46.2% in Group 2 (p = 0.022). Capsule endoscopy findings prompted specific measures or patient management changes in 39.5% of patients. Conclusions. Capsule endoscopy has a high diagnostic yield in patients with suspected Crohn's disease and both clinical and biochemical markers of inflammation. (c) 2006 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.