Cyclophosphamide and related anticancer drugs

被引：87

作者：

Baumann, F ^{[1
]}

Preiss, R ^{[1
]}

机构：

[1] Univ Leipzig, Inst Clin Pharmacol, D-04107 Leipzig, Germany

来源：

JOURNAL OF CHROMATOGRAPHY B | 2001年 / 764卷 / 1-2期

关键词：

reviews; oxazaphosphorines; cyclophosphamide; ifosfamide; trofosfamide;

D O I：

10.1016/S0378-4347(01)00279-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This article presents an overview of the methods of bioanalysis of oxazaphosphorines, in particular, cyclophosphamide, ifosfamide, and trofosfamide as well as their metabolites. The metabolism of oxazaphosphorines is complex and leads to a large variety of metabolites and therefore the spectrum of methods used is relatively broad. The various methods used are shown in a table and the particularly important assays are described. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：173 / 192

页数：20

共 159 条

[1] FLUOROMETRIC DETERMINATION OF ACROLEIN AND RELATED COMPOUNDS WITH M-AMINOPHENOL [J].

ALARCON, RA .

ANALYTICAL CHEMISTRY, 1968, 40 (11) :1704-&

[2] DETERMINATION OF ACROLEIN IN URINE BY LIQUID-CHROMATOGRAPHY AND FLUORESCENCE DETECTION OF ITS QUINOLINE DERIVATIVE [J].

ALRAWITHI, S ;

ELYAZIGI, A ;

NICHOLLS, PJ .

PHARMACEUTICAL RESEARCH, 1993, 10 (11) :1587-1590

[3] QUANTITATION OF 4-HYDROXYCYCLOPHOSPHAMIDE ALDOPHOSPHAMIDE IN WHOLE-BLOOD [J].

ANDERSON, LW ;

LUDEMAN, SM ;

COLVIN, OM ;

GROCHOW, LB ;

STRONG, JM .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 667 (02) :247-257

[4] QUANTITATIVE FIELD DESORPTION MASS-SPECTROMETRY .24. ISOLATION, IDENTIFICATION AND DETERMINATION OF CYCLOPHOSPHAMIDE AND 2 OF ITS METABOLITES IN URINE OF A MULTIPLE-SCLEROSIS PATIENT BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY AND FIELD DESORPTION MASS-SPECTROMETRY [J].

BAHR, U ;

SCHULTEN, HR .

BIOMEDICAL MASS SPECTROMETRY, 1981, 8 (11) :553-557

[5] Determination of cyclophosphamide and its metabolites in human plasma by high-performance liquid chromatography-mass spectrometry [J].

Baumann, F ;

Lorenz, C ;

Jaehde, U ;

Preiss, R .

JOURNAL OF CHROMATOGRAPHY B, 1999, 729 (1-2) :297-305

[6] SOLVENT SAMPLE INTERACTIONS IN THERMOSPRAY MASS-SPECTROMETRY OF ANTINEOPLASTIC NITROGEN MUSTARDS [J].

BEAN, MF ;

PALLANTEMORELL, SL ;

FENSELAU, C .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1989, 18 (04) :219-223

[7] MEASUREMENT OF 4-HYDROXYCYCLOPHOSPHAMIDE IN SERUM BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BELFAYOL, L ;

GUILLEVIN, L ;

LOUCHAHI, K ;

LORTHOLARY, O ;

BOSIO, AM ;

FAUVELLE, F .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 663 (02) :395-399

[8] N-(2-HYDROXYETHYL)-N-[2-(7-GUANINYL)ETHYL]AMINE, THE PUTATIVE MAJOR DNA ADDUCT OF CYCLOPHOSPHAMIDE INVITRO AND INVIVO IN THE RAT [J].

BENSON, AJ ;

MARTIN, CN ;

GARNER, RC .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (15) :2979-2985

[9]

BLASCHKE G, 1986, ARZNEIMITTEL-FORSCH, V36-2, P1493

[10]

BLASCHKE G, 1989, ARZNEIMITTEL-FORSCH, V39-1, P223

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