Biofabrication for osteochondral tissue regeneration: bioink printability requirements

被引：41

作者：

Abdulghani, Saba ^{[1
]}

Morouco, Pedro G. ^{[1
]}

机构：

[1] Polytech Inst Leiria, Ctr Rapid & Sustainable Prod Dev, Rua Portugal Zona Ind, P-2430028 Marinha Grande, Portugal

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2019年 / 30卷 / 02期

关键词：

ARTICULAR-CARTILAGE; MECHANICAL-PROPERTIES; BIODEGRADABLE HYDROGELS; NANOCOMPOSITE HYDROGELS; ENGINEERED CARTILAGE; ELASTIC-MODULUS; STEM-CELLS; DESIGN; SCAFFOLDS; REPAIR;

D O I：

10.1007/s10856-019-6218-x

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Biofabrication allows the formation of 3D scaffolds through a precise spatial control. This is of foremost importance when aiming to mimic heterogeneous and anisotropic architecture, such as that of the osteochondral tissue. Osteochondral defects are a supreme challenge for tissue engineering due to the compositional and structural complexity of stratified architecture and contrasting biomechanical properties of the cartilage-bone interface. This review highlights the advancements and retreats witnessed by using developed bioinks for tissue regeneration, taking osteochondral tissue as a challenging example. Methods, materials and requirements for bioprinting were discussed, highlighting the pre and post-processing factors that researchers should consider towards the development of a clinical treatment.

引用

页数：13

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