Bone regeneration and stem cells

被引:277
作者
Arvidson, K. [1 ]
Abdallah, B. M. [2 ,12 ]
Applegate, L. A. [3 ]
Baldini, N. [4 ]
Cenni, E. [4 ]
Gomez-Barrena, E. [5 ]
Granchi, D. [4 ]
Kassem, M. [2 ,6 ,12 ]
Konttinen, Y. T. [7 ,8 ,9 ]
Mustafa, K. [1 ]
Pioletti, D. P. [3 ,10 ]
Sillat, T. [7 ]
Finne-Wistrand, A. [11 ]
机构
[1] Univ Bergen, Fac Med & Dent, Clin Res Ctr, Dept Clin Dent, N-5009 Bergen, Norway
[2] Univ So Denmark, Odense Univ Hosp, Dept Endocrinol, Mol Endocrinol Lab, Odense, Denmark
[3] Univ Lausanne Hosp, Cellular Therapy Unit, Serv Plast & Reconstruct Surg, Dept Musculoskeletal Med, Lausanne, Switzerland
[4] Ist Ortoped Rizzoli, Lab Orthopaed Pathophysiol & Regenerat Med, Bologna, Italy
[5] Univ Autonoma Madrid, Hosp Univ La Paz, Serv Cirurg Ortoped & Traumatol, Madrid, Spain
[6] King Saud Univ, Coll Med, Dept Anat, Stem Cell Unit, Riyadh 11461, Saudi Arabia
[7] Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland
[8] ORTON Orthopaed Hosp, ORTON Fdn, Helsinki, Finland
[9] COXA Hosp Joint Replacement, Tampere, Finland
[10] Ecole Polytech Fed Lausanne, Inst Bioengn, Lab Biomech Orthoped, Lausanne, Switzerland
[11] Royal Inst Technol, Sch Chem Sci & Engn, Stockholm, Sweden
[12] Univ So Denmark, Ctr Med Biotechnol, Odense, Denmark
基金
英国医学研究理事会; 瑞士国家科学基金会;
关键词
bone regeneration; stem cells; biomaterials; polymers; regenerative medicine; PLATELET-RICH PLASMA; MARROW STROMAL CELLS; GROWTH-FACTOR-BETA; MESENCHYMAL PROGENITOR CELLS; CRITICAL-SIZE DEFECTS; OSTEOGENIC DIFFERENTIATION; GENE-EXPRESSION; AUTOGENOUS BONE; IN-VIVO; OSTEOBLAST DIFFERENTIATION;
D O I
10.1111/j.1582-4934.2010.01224.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Introduction Bone fracture healing and healing problems Biomaterial scaffolds and tissue engineering in bone formation Bone tissue engineering Biomaterial scaffolds Synthetic scaffolds Micro- and nanostructural properties of scaffolds Conclusion Mesenchymal stem cells and osteogenesis Bone tissue Origin of osteoblasts Isolation and characterization of bone marrow derived MSC In vitro differentiation of MSC into osteoblast lineage cells In vivo differentiation of MSC into bone Factors and pathways controlling osteoblast differentiation of hMSC Defining the relationship between osteoblast and adipocyte differentiation from MSC MSC and sex hormones Effect of aging on osteoblastogenesis Conclusion Embryonic, foetal and adult stem cells in osteogenesis Cell-based therapies for bone Specific features of bone cells needed to be advantageous for clinical use Development of therapeutic biological agents Clinical application concerns Conclusion Platelet-rich plasma (PRP), growth factors and osteogenesis PRP effects in vitro on the cells involved in bone repair PRP effects on osteoblasts PRP effects on osteoclasts PRP effects on endothelial cells PRP effects in vivo on experimental animals The clinical use of PRP for bone repair Non-union Distraction osteogenesis Spinal fusion Foot and ankle surgery Total knee arthroplasty Odontostomatology and maxillofacial surgery Conclusion Molecular control of osteogenesis TGF-beta signalling FGF signalling IGF signalling PDGF signalling MAPK signalling pathway Wnt signalling pathway Hedgehog signalling Notch signalling Ephrin signalling Transcription factors regulating osteoblast differentiation Conclusion Summary This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, effects of sex steroids on mesenchymal stem cells, use of platelet-rich plasma for tissue repair, osteogenesis and its molecular markers. A variety of cells in addition to stem cells, as well as advances in materials science to meet specific requirements for bone and soft tissue regeneration by addition of bioactive molecules, are discussed.
引用
收藏
页码:718 / 746
页数:29
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