Drug Insight: using statins to treat neuroinflammatory disease

被引：22

作者：

Weber, MS

Prod'homme, T

Steinman, L

Zamvil, SS

机构：

[1] Univ Calif San Francisco, Program Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[3] Stanford Univ, Program Immunol, Stanford, CA 94305 USA

来源：

NATURE CLINICAL PRACTICE NEUROLOGY | 2005年 / 1卷 / 02期

关键词：

immunomodulation; multiple sclerosis; neuroinflammatory disease; statins;

D O I：

10.1038/ncpneuro0047

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Statins, a family of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are used primarily to reduce atherogenesis and cardiovascular morbidity. Surprisingly, they have also been shown to have immunomodulatory properties that might be of benefit for the treatment of autoimmune disorders. Statins can prevent and even reverse ongoing paralysis in experimental autoimmune encephalomyelitis - the mouse model for multiple sclerosis - and on the basis of these findings, statins are now being tested in patients with multiple sclerosis in clinical trials.

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收藏

页码：106 / 112

页数：7

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