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The adenomatous polyposis coli protein

被引：17
作者：
Näthke, IS [1 ]
机构：
[1] Univ Dundee, Dept Anat & Physiol, WTB, MSI, Dundee DD1 5EH, Scotland
来源：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 1999年 / 52卷 / 04期
关键词：
adenomatous polyposis coli gene; colorectal cancer; familial polyposis; Wnt signalling pathway;
D O I：
10.1136/mp.52.4.169
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.
引用
收藏
页码：169 / 173
页数：5
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