Mucin-type O-glycans and their roles in intestinal homeostasis

被引：253

作者：

Bergstrom, Kirk S. B. ^{[1
]}

Xia, Lijun ^{[1
]}

机构：

[1] Oklahoma Med Res Fdn, Cardiovasc Biol Res Program, Oklahoma City, OK 73104 USA

来源：

GLYCOBIOLOGY | 2013年 / 23卷 / 09期

关键词：

intestinal homeostasis; microbiota; mucin; mucin-type O-glycans; colitis; GLYCOSIDE HYDROLASE FAMILY; IN-VITRO UTILIZATION; 2 MUCUS LAYERS; MOLECULAR-CLONING; BLOOD-GROUP; BACTERIAL SYMBIONTS; TARGETED DELETION; ESCHERICHIA-COLI; GUT; COMMENSAL;

D O I：

10.1093/glycob/cwt045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mucin-type O-glycans are the primary constituents of mucins that are expressed on various mucosal sites of the body, especially the bacteria-laden intestinal tract. Mucins are the main components of mucus, which is secreted by goblet cells and forms a protective homeostatic barrier between the resident microbiota and the underlying immune cells in the colon. However, the specific role of mucin-type O-glycans in mucus barrier function has been uncertain. Recent studies utilizing mice deficient in key glycosyltransferases involved in O-glycan biosynthesis on intestinal mucins have underscored the importance of mucin-type O-glycosylation in mucus barrier function. This review will highlight recent advances in our understanding of mucin-type O-glycan function in the mucus barrier and how they promote mutualism with our resident microbiota.

引用

页码：1026 / 1037

页数：12

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