Isolation and activity of N-p-coumaroyltyramine, an alpha-glucosidase inhibitor in Welsh onion (Allium fistulosum)

被引：72

作者：

Nishioka, T ^{[1
]}

Watanabe, J ^{[1
]}

Kawabata, J ^{[1
]}

Niki, R ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC AGR, DEPT BIOSCI & CHEM, KITA KU, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 07期

关键词：

alpha-glucosidase inhibitor; N-p-coumaroyltyramine; Allium fistulosum;

D O I：

10.1271/bbb.61.1138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phenolic amide, N-p-coumaroyltyramine (1), was isolated as an alpha-glucosidase inhibitor from methanol extracts of Welsh onion (Allium fistulosum). The inhibitory activity of 1 against a yeast enzyme was as high as K-i 8.4 x 10(-7) M. From a structure-activity relationship study of 1 and its related compounds, the occurrence of alpha-glucosidase inhibitory activity required a p-coumaramide structure, with an amide hydrogen and alkyl or aralkyl substituent on the amide part.

引用

页码：1138 / 1141

页数：4

共 8 条

[1]

GODA Y, 1987, CHEM PHARM BULL, V35, P2668

[2] SULFOQUINOVOSYLDIACYLGLYCEROL AS AN ALPHA-GLUCOSIDASE INHIBITOR [J].

KURIHARA, H ;

ANDO, J ;

HATANO, M ;

KAWABATA, J .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (12) :1241-1244

[3] PREPARATION OF ESTERS OF CARBOXYLIC AND PHOSPHORIC ACID VIA QUATERNARY PHOSPHONIUM SALTS [J].

MITSUNOBU, O ;

YAMADA, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1967, 40 (10) :2380-+

[4]

Mowry D.T., 1963, ORG SYNTH, VIV, P486

[5]

OKUYAMA T, 1986, PLANTA MED, P171, DOI 10.1055/s-2007-969113

[6] Concise synthesis of a racemic and diastereomeric mixture of the sex pheromones of Matsucoccus pine scales [J].

Watanabe, H ;

Watanabe, T ;

Kitahara, T ;

Mori, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1997, 61 (01) :127-130

[7] AMINO-SUGAR GLYCOSIDASE INHIBITORS - VERSATILE TOOLS FOR GLYCOBIOLOGISTS [J].

WINCHESTER, B ;

FLEET, GWJ .

GLYCOBIOLOGY, 1992, 2 (03) :199-210

[8] 3 NEW PHENOLIC AMIDES FROM ROOTS OF EGGPLANT (SOLANUM-MELONGENA L) [J].

YOSHIHARA, T ;

TAKAMATSU, S ;

SAKAMURA, S .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1978, 42 (03) :623-627

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