Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection

被引：78

作者：

Nishizawa, T

Okamoto, H

Tsuda, F

Aikawa, T

Sugai, Y

Konishi, K

Akahane, Y

Ukita, M

Tanaka, T

Miyakawa, Y

Mayumi, M ^{[1
]}

机构：

[1] Jichi Med Sch, Div Immunol, Minami Kawachi, Tochigi 3290498, Japan

[2] Jichi Med Sch, Div Mol Virol, Minami Kawachi, Tochigi 3290498, Japan

[3] Toshiba Gen Hosp, Dept Med Sci, Tokyo 1408522, Japan

[4] Aikawa Internal Hosp, Mito, Ibaraki 3100851, Japan

[5] Iwaki Kyoritsu Gen Hosp, Dept Internal Med, Iwaki, Fukushima 9738402, Japan

[6] Kanazawa Natl Hosp, Dept Clin Pathol, Kanazawa, Ishikawa 9200935, Japan

[7] Yamanashi Med Univ, Dept Internal Med 1, Tamaho, Yamanashi 4093898, Japan

[8] Japanese Red Cross Saitama Blood Ctr, Urawa, Saitama 3380001, Japan

[9] Miyakawa Mem Res Fdn, Tokyo, Japan

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 11期

关键词：

D O I：

10.1128/JVI.73.11.9604-9608.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

引用

收藏

页码：9604 / 9608

页数：5

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