Helicobacter pylori phase variation, immune modulation and gastric autoimmunity

被引：78

作者：

Bergman, M

Del Prete, G

van Kooyk, Y

Appelmelk, B

机构：

[1] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, NL-3015 GD Rotterdam, Netherlands

[2] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

[3] Free Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands

[4] Free Univ Amsterdam, Med Ctr, Dept Med Microbiol & Infect Control, NL-1081 BT Amsterdam, Netherlands

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrmicro1344

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.

引用

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页码：151 / 159

页数：10

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