Squamotacin: An annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3)

被引：45

作者：

Hopp, DC ^{[1
]}

Zeng, L ^{[1
]}

Gu, ZM ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 02期

关键词：

D O I：

10.1021/np960124i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bark extracts of Annona squamosa yielded a new bioactive acetogenin, squamotacin (1), and the known compound, molvizarin (2), which is new to this species. Compound 1 is identical to the potent acetogenin, bullatacin (3), except that the adjacent bis-tetrahydrofuran (THF) rings and their nanking hydroxyls are shifted two carbons toward the gamma-lactone ring. Compound 1 showed cytotoxic selectively for the human prostate tumor cell line (PC-3), with a potency of over 100 million times that of Adriamycin.

引用

页码：97 / 99

页数：3

共 21 条

[1] ACETOGENINS OF ANNONACEAE .12. MOLVIZARIN AND MOTRILIN - 2 NOVEL CYTOTOXIC BIS-TETRAHYDROFURANIC GAMMA-LACTONE ACETOGENINS FROM ANNONA-CHERIMOLIA [J].

CORTES, D ;

MYINT, SH ;

HOCQUEMILLER, R .

TETRAHEDRON, 1991, 47 (38) :8195-8202

[2] ACETOGENINS OF THE ANNONACEAE .21. BIS-TETRAHYDROFURAN ACETOGENINS FROM ANNONACEAE [J].

CORTES, D ;

FIGADERE, B ;

CAVE, A .

PHYTOCHEMISTRY, 1993, 32 (06) :1467-1473

[3] ANNONACEOUS ACETOGENINS - AN UPDATED REVIEW [J].

FANG, XP ;

RIESER, MJ ;

GU, ZM ;

ZHAO, GX ;

MCLAUGHLIN, JL .

PHYTOCHEMICAL ANALYSIS, 1993, 4 (01) :27-48

[4]

FOGH J, 1973, HUMAN TUMOR CELLS, P115

[5] IN-VITRO CULTIVATION OF HUMAN TUMORS - ESTABLISHMENT OF CELL LINES DERIVED FROM A SERIES OF SOLID TUMORS [J].

GIARD, DJ ;

AARONSON, SA ;

TODARO, GJ ;

ARNSTEIN, P ;

KERSEY, JH ;

DOSIK, H ;

PARKS, WP .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (05) :1417-1423

[6]

GU ZM, IN PRESS RECENT ADV, V27

[7] BULLATACIN AND BULLATACINONE - 2 HIGHLY POTENT BIOACTIVE ACETOGENINS FROM ANNONA-BULLATA [J].

HUI, YH ;

RUPPRECHT, JK ;

LIU, YM ;

ANDERSON, JE ;

SMITH, DL ;

CHANG, CJ ;

MCLAUGHLIN, JL .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (03) :463-477

[8]

KAIGHN ME, 1979, INVEST UROL, V17, P16

[9] BULLATACIN, BULLATACINONE, AND SQUAMONE, A NEW BIOACTIVE ACETOGENIN, FROM THE BARK OF ANNONA-SQUAMOSA [J].

LI, XH ;

HUI, YH ;

RUPPRECHT, JK ;

LIU, YM ;

WOOD, KV ;

SMITH, DL ;

CHANG, CJ ;

MCLAUGHLIN, JL .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (01) :81-86

[10] MOLECULAR-MODE OF ACTION OF ANNONINS [J].

LONDERSHAUSEN, M ;

LEICHT, W ;

LIEB, F ;

MOESCHLER, H ;

WEISS, H .

PESTICIDE SCIENCE, 1991, 33 (04) :427-438

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