Squamotacin: An annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3)

被引：45

作者：

Hopp, DC ^{[1
]}

Zeng, L ^{[1
]}

Gu, ZM ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 02期

关键词：

D O I：

10.1021/np960124i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bark extracts of Annona squamosa yielded a new bioactive acetogenin, squamotacin (1), and the known compound, molvizarin (2), which is new to this species. Compound 1 is identical to the potent acetogenin, bullatacin (3), except that the adjacent bis-tetrahydrofuran (THF) rings and their nanking hydroxyls are shifted two carbons toward the gamma-lactone ring. Compound 1 showed cytotoxic selectively for the human prostate tumor cell line (PC-3), with a potency of over 100 million times that of Adriamycin.

引用

页码：97 / 99

页数：3