Striatum specific protein, Rhes regulates AKT pathway

被引：26

作者：

Bang, Sookhee ^{[1
]}

Steenstra, Catherine ^{[1
]}

Kim, Sangwon F. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Ctr Neurobiol & Behav, Dept Psychiat & Pharmacol, Philadelphia, PA 19104 USA

来源：

NEUROSCIENCE LETTERS | 2012年 / 521卷 / 02期

关键词：

AKT signal transduction; Rhes/RASD2; Protein-protein interaction; GTP-BINDING PROTEIN; CEREBRAL-CORTEX; DOPAMINE; RECEPTORS; BEHAVIOR; ACTIVATION; EXPRESSION; DEXRAS1; CELLS; GENE;

D O I：

10.1016/j.neulet.2012.05.073

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The Rhes/RASD2 GTPase complex is involved in dopamine D1/D2 receptor-mediated signaling and behavior. This GTP binding protein belongs to the RAS superfamily, along with Dexras1/RASD1, and is primarily expressed in the striatum. RASDs differ from typical small GTPases as they have an extended C-terminal tail of roughly 7 kDa. Previously, it has been shown that dopamine depletion reduces Rhes mRNA expression in the brain. Here we show that Rhes interacts with p85, the regulatory subunit of PI3K. Specifically, the C-terminal unique tail region of Rhes is responsible for this interaction. The interaction between p85 and the C-terminal region of Rhes is enhanced upon growth factor treatment in vitro, while Ala translocation to the membrane is facilitated in the presence of Rhes or the Rhes-p85 complex. These findings suggest that Rhes is a novel striatal regulator of the AKT-mediated pathway in the striatum. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：142 / 147

页数：6

共 25 条

[1]

Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during pre- and postnatal development [J].