The Genetics of Diabetic Nephropathy

被引：35

作者：

Brennan, Eoin ^{[1
]}

McEvoy, Caitriona ^{[1
,2
]}

Sadlier, Denise ^{[2
]}

Godson, Catherine ^{[1
]}

Martin, Finian ^{[3
]}

机构：

[1] Univ Coll Dublin, Sch Med & Med Sci, Diabet Complicat Res Ctr, Conway Inst Biomol & Biomed Res, Dublin 2, Ireland

[2] Mater Misericordiae Univ Hosp, Dublin 7, Ireland

[3] Univ Coll Dublin, Sch Biomol & Biomed Sci, Conway Inst Biomol & Biomed Res, Dublin 2, Ireland

来源：

GENES | 2013年 / 4卷 / 04期

基金：

美国国家卫生研究院; 爱尔兰科学基金会;

关键词：

diabetes mellitus; diabetic nephropathy; genome-wide association study; single nucleotide polymorphism; GENOME-WIDE ASSOCIATION; GROWTH-FACTOR-BETA; CONVERTING-ENZYME GENE; URINARY ALBUMIN EXCRETION; RENIN-ANGIOTENSIN SYSTEM; GLYCATION END-PRODUCTS; TGF-BETA; HIGH GLUCOSE; KIDNEY-DISEASE; RENAL INJURY;

D O I：

10.3390/genes4040596

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the key molecular mechanisms and genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.

引用

页码：596 / 619

页数：24

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