Increased IL-35 serum levels in systemic sclerosis and association with pulmonary interstitial involvement

被引：28

作者：

Dantas, Andrea Tavares ^{[1
,2
]}

Calado Goncalves, Sayonara Maria ^{[1
]}

Pereira, Michelly Cristiny ^{[1
]}

Guimaraes Goncalves, Rafaela Silva ^{[1
,2
]}

Lopes Marques, Claudia Diniz ^{[2
]}

Barreto de Melo Rego, Moacyr Jesus ^{[1
]}

Pitta, Ivan da Rocha ^{[1
]}

Branco Pinto Duarte, Angela Luzia ^{[2
]}

da Rocha Pitta, Maira Galdino ^{[1
]}

机构：

[1] Lab Imunomodulacao & Novas Abordagens Terapeut, Recife, PE, Brazil

[2] Univ Fed Pernambuco, Hosp Clin, Serv Reumatol, Recife, PE, Brazil

来源：

CLINICAL RHEUMATOLOGY | 2015年 / 34卷 / 09期

关键词：

Cytokine; Interleukin-35; Pulmonary fibrosis; Systemic sclerosis; REGULATORY T-CELLS; INDUCED ARTHRITIS; TH17; CELLS; CYTOKINES;

D O I：

10.1007/s10067-015-3006-y

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The objective of this study is to assess the serum IL-35 level and its association with clinical manifestations in patients with systemic sclerosis (SSc). IL-35 serum levels were measured by ELISA from 56 patients with SSc and 53 healthy controls. Association of IL-35 serum levels were sought with clinical parameters. Serum IL-35 levels were significantly higher in SSc patients (5.08 +/- 0.76 pg/ml) than in healthy individuals (1.89 +/- 0.69 pg/ml; p < 0.0001). Patients with lung fibrosis had higher IL-35 levels than those without fibrosis (7.75 +/- 1.36 and 3.08 +/- 0.70 pg/ml, respectively, p = 0.0022). IL-35 is elevated in the serum of patients with SSc and is associated with lung fibrosis. Our findings suggest that this cytokine can have a role in fibrotic diseases, but further studies are needed to address the role of IL-35 in the pathogenesis of SSc.

引用

页码：1621 / 1625

页数：5

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