Use-related gene expression patterns of rat motor cortex

被引:7
作者
Keyvani, K [1 ]
Witte, OW
Reinecke, S
Paulus, W
机构
[1] Univ Munster, Inst Neuropathol, D-4400 Munster, Germany
[2] Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany
关键词
gene expression profiles; rat motor cortex; real-time-PCR; use-induced plasticity;
D O I
10.1097/00001756-200205240-00010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Current evidence indicates reorganization of motor cortex in association with motor behavior. To investigate the molecular basis for these changes rats were fitted with limb-restricting vests which forced the use of one forelimb for 10 days. Using cDNA macroarrays, expression profiles of the corresponding motor cortices connected to the overused and immobilized limbs were analyzed. In the overused motor cortex up-regulations were observed exclusively, including genes coding for voltage-gated ion channels, trafficking and targeting proteins, and intracellular kinase network members (10 genes). In the contralateral immobilized cortex changes were restricted to down-regulation, mainly involving genes pertaining to DNA-binding, translation, neuronal signaling and metabolic pathways (9 genes). At least some of these changes are likely to represent the molecular substrate of use-dependent plasticity, NeuroReport 13:953-956 (C) 2002 Lippincott Williams Wilkins.
引用
收藏
页码:953 / 956
页数:4
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