Implications of sperm chromosome abnormalities in recurrent miscarriage

被引：77

作者：

Rubio, C ^{[1
]}

Simón, C ^{[1
]}

Blanco, J ^{[1
]}

Vidal, F ^{[1
]}

Mínguez, Y ^{[1
]}

Egozcue, J ^{[1
]}

Crespo, J ^{[1
]}

Remohí, J ^{[1
]}

Pellicer, A ^{[1
]}

机构：

[1] Inst Valenciano Infertil, E-46020 Valencia, Spain

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1999年 / 16卷 / 05期

关键词：

unexplained recurrent miscarriage; chromosome abnormalities; sperm; nuclei; fluorescence in situ hybridization;

D O I：

10.1023/A:1020315529090

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: Our purpose was to assess the existence of sperm chromosome abnormalities in recurrent pregnancy loss in an assisted reproduction program. Methods: In this prospective study. 12 sperm samples from couples undergoing in vitro fertilization with two or more first-trimester spontaneous abortions were analyzed. Diploidy and disomy in decondensed sperm nuclei were assessed for chromosomes 13, 18, 21, X, and Y using two- and three-color fluorescence in situ hybridization. Results: Sex chromosome disomy in sperm samples from recurrent abortion couples was significantly increased compared to that from internal controls (0.84% vs 0.37%). In a subpopulation of seven couples who underwent oocyte donation, mean frequencies for sex chromosome disomy (1%) were even higher and diploidy (0.43%) was also significantly increased. Conclusions: These results suggest an implication of sperm chromosome abnormalities in some cases of recurrent pregnancy loss.

引用

页码：253 / 258

页数：6

共 33 条

[1] THE EURO-TEAM EARLY-PREGNANCY (ETEP)ASTERISK PROTOCOL FOR RECURRENT MISCARRIAGE [J].