Synthesis of (±) cis-substituted cyclohexenyl and cyclohexanyl nucleosides via a double Mitsunobu-type reaction

被引：15

作者：

Barral, K

Halfon, P

Pèpe, G

Camplo, M

机构：

[1] Fac Sci Luminy, Grp Chim Organ & Mat Mol, UMR CNRS 6114, F-288 Marseille 09, France

[2] GenoSci, Marseille, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 01期

关键词：

cyclohexenyl and cyclohexanyl nucleosides; carbocyclic nucleosides; Mitsunobu reaction;

D O I：

10.1016/S0040-4039(01)02107-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This letter describes the synthesis of (+/-) cis-substituted cyclohexenyl and cyclohexanyl nucleosides. The synthesis of cis isomers was successfully achieved by the use of two consecutive Mitsunobu reactions involving an inversion of configuration and a sugar-base condensation. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：81 / 84

页数：4

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