Transferable DHA-1 cephalosporinase in Escherichia coli

被引：16

作者：

Giakkoupi, P

Tambic-Andrasevic, A

Vourli, S

Skrlin, J

Sestan-Crnek, S

Tzouvelekis, LS

Vatopoulos, AC

机构：

[1] Natl Sch Publ Hlth, Dept Microbiol, Athens 11521, Greece

[2] Univ Zagreb, Univ Hosp Infect Dis, Zagreb, Croatia

[3] Univ Zagreb, Univ Hosp Dubrava, Zagreb, Croatia

[4] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 27卷 / 01期

关键词：

DHA-1; cephalosporinase; Escherichia coli; Croatia;

D O I：

10.1016/j.ijantimicag.2005.09.013

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Three Escherichia coli isolates resistant to third-generation cephalosporins but negative for extended-spectrum P-lactamase production were isolated from hospitalised patients in Zagreb, Croatia, during June 2003 to February 2004. Resistance was due to the inducible production of a DHA-1 cephalosporinase. Each isolate contained an integron-associated bla(DHA-1)-ampR sequence carried by similar-sized plasmids, of which one was self-transferable. Serotyping and polymerase chain reaction typing using ERIC2 primer indicated that the isolates were distinct. This is the first description of DHA beta-lactamase production in E. coli. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：77 / 80

页数：4

共 15 条

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