New photolabile protecting groups of the 2-(2-nitrophenyl)ethoxycarbonyl- and the 2-(2-nitrophenyl)ethylsulfonyl-type for the oligonucleotide synthesis

被引:3
作者
Bühler, S
Giegrich, H
Pfleiderer, W
机构
[1] Univ Konstanz, Fak Chem, D-78457 Constance, Germany
[2] Nigu Chem, D-84469 Waldkraiburg, Germany
来源
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期
关键词
D O I
10.1080/07328319908044692
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
New photolabile blocking groups have been synthesized and introduced into the 5'-OH position of thymidine. The 5'-O-protected thymidines were irradiated at 365 nm under identical conditions and the half-lives and thymidine yields were determined to investigate the influence of different substituents in the two corresponding series.
引用
收藏
页码:1281 / 1283
页数:3
相关论文
共 7 条
[1]   NEW SYNTHESES OF SUBSTITUTED INDOLES [J].
BAKKE, J .
ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1974, B 28 (01) :134-135
[2]   THE E2-TRANSITION STATE - ELIMINATION-REACTIONS OF 2-(2,4-DINITROPHENYL)ETHYL HALIDES [J].
GANDLER, JR ;
YOKOYAMA, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (01) :130-135
[3]   Photolabile protecting groups for nucleosides: Synthesis and photodeprotection rates [J].
Hasan, A ;
Stengele, KP ;
Giegrich, H ;
Cornwell, P ;
Isham, KR ;
Sachleben, RA ;
Pfleiderer, W ;
Foote, RS .
TETRAHEDRON, 1997, 53 (12) :4247-4264
[4]   SULFOSTYRIL (2,1-BENZOTHIAZINE 2,2-DIOXIDE) .I. PREPARATION AND REACTIONS OF 3,4-D2HYDROSULFOSTYRIL [J].
LOEV, B ;
KORMENDY, MF .
JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (09) :3163-&
[5]   NUCLEOSIDES .59. THE 2-(4-NITROPHENYL)ETHYLSULFONYL (NPES) GROUP - A NEW-TYPE OF PROTECTION IN NUCLEOSIDE CHEMISTRY [J].
PFISTER, M ;
SCHIRMEISTER, H ;
MOHR, M ;
FARKAS, S ;
STENGELE, KP ;
REINER, T ;
DUNKEL, M ;
GOKHALE, S ;
CHARUBALA, R ;
PFLEIDERER, W .
HELVETICA CHIMICA ACTA, 1995, 78 (07) :1705-1737
[6]   ELECTROGENERATED BASE (EG BASE) INDUCED HYDROXYMETHYLATION OF THE SIDE-CHAIN OF NITROALKYLBENZENES WITH PARAFORMALDEHYDE [J].
TORII, S ;
MURAKAMI, Y ;
TANAKA, H ;
OKAMOTO, K .
JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (16) :3143-3147
[7]   ALDOL REACTIONS OF FORMALDEHYDE IN NON-AQUEOUS MEDIA .2. BASE-CATALYZED REACTION OF FLUORENE AND NITROTOLUENES WITH FORMALDEHYDE IN DIMETHYL SULFOXIDE [J].
WESSLEN, B .
ACTA CHEMICA SCANDINAVICA, 1967, 21 (03) :718-&