Sialoglycans in protozoal diseases: Their detection, modes of acquisition and emerging biological roles

被引:13
作者
Chava, AK
Bandyopadhyay, S
Chatterjee, M
Mandal, C
机构
[1] Indian Inst Chem Biol, Immunobiol Div, Kolkata 700032, W Bengal, India
[2] Postgrad Inst Med Educ & Res, Dr BC Roy Postgrad Inst Basic Med Sci, Dept Pharmacol, Kolkata 700020, W Bengal, India
关键词
sialic acid; O-acetylated sialic acid; parasite; trans-sialidases; UDP-GlcNAc(2)-epimerase;
D O I
10.1023/B:GLYC.0000024251.30100.08
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protozoan parasites including Plasmodia, Leishmania, Trypanosoma, Entamoeba, Trichomonas and others cause diseases in humans and domestic livestock having far-reaching socio-economic implications. They show remarkable propensity to survive within hostile environments encountered during their life cycle, and the identification of molecules that enable them to survive in such milieu is a subject of intense research. Currently available knowledge of the parasite cell surface architecture and biochemistry indicates that sialic acid and its principle derivatives are major components of the glycocalyx and assist the parasite to interact with its external environment through functions ranging from parasite survival, infectivity and host-cell recognition. This review highlights the present state of knowledge with regard to parasite sialobiology with an emphasis on its mode(s) of acquisition and their emerging biological roles, notably as an anti-recognition molecule thereby aiding the pathogen to evade host defense mechanisms. Published in 2004.
引用
收藏
页码:199 / 206
页数:8
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