TGF-β signalling and its role in cancer progression and metastasis

被引：418

作者：

Drabsch, Yvette ^{[1
,2
]}

ten Dijke, Peter ^{[1
,2
,3
,4
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Ctr Biomed Genet, NL-2300 RC Leiden, Netherlands

[3] Uppsala Univ, S-75124 Uppsala, Sweden

[4] Ludwig Inst Canc Res, S-75124 Uppsala, Sweden

来源：

CANCER AND METASTASIS REVIEWS | 2012年 / 31卷 / 3-4期

关键词：

TGF-beta signalling; SMAD; Cancer; Epithelial to mesenchymal transition; TRANSFORMING-GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; INVASIVE BREAST-CANCER; BONE MORPHOGENETIC PROTEIN; COLORECTAL-CANCER; IN-VIVO; COLON-CANCER; C-MYC; TUMOR-SUPPRESSOR; DRUG-RESISTANCE;

D O I：

10.1007/s10555-012-9375-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The transforming growth factor-beta (TGF-beta) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-beta signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-beta acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-beta signalling pathway, its involvement in cancer and current therapeutic approaches.

引用

页码：553 / 568

页数：16

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