DNA double-strand break repair by homologous recombination

被引：157

作者：

Dudás, A ^{[1
]}

Chovanec, M ^{[1
]}

机构：

[1] Slovak Acad Sci, Canc Res Inst, Mol Genet Lab, Bratislava 83391 37, Slovakia

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2004年 / 566卷 / 02期

关键词：

DNA double-strand breaks; DNA double-strand break repair; homologous recombination; RAD52 epistasis group; Saccharomyces cerevisiae; vertebrate cells; mammalian cells; protein-protein interactions;

D O I：

10.1016/j.mrrev.2003.07.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA double-strand breaks (DSB) are presumed to be the most deleterious DNA lesions as they disrupt both DNA strands. Homologous recombination (HR), single-strand annealing, and non-homologous end-joining are considered to be the pathways for repairing DSB. In this review. we focus on DSB repair by HR. The proteins involved in this process as well as the interactions among them are summarized and characterized. The main emphasis is on eukaryotic cells, particularly the budding yeast Saccharomyces cerevisiae and mammals. Only the RAD52 epistasis group proteins are included. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：131 / 167

页数：37

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