Syndecan-2

被引：84

作者：

Essner, JJ

Chen, E

Ekker, SC ^{[3
]}

机构：

[1] Discovery Genom Inc, Minneapolis, MN 55413 USA

[2] Univ Minnesota, Sch Med, Combined MD PhD Program, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Arnold & Mabel Beckman Ctr Transposon Res, Minneapolis, MN 55455 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2006年 / 38卷 / 02期

关键词：

Syndecan-2; angiogenesis; cell signaling; cell adhesion;

D O I：

10.1016/j.biocel.2005.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The members of the Syndecan family of heparan sulfate proteoglycans play diverse roles in cell adhesion and cell communication by serving as co-receptors for both cell-signaling and extracellular matrix molecules. Syndecan-2 has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recent studies have shown that syndecan-2 is required for angiogenesis, possibly by serving as a co-receptor for vascular endothelial growth factor, and cell-to-cell signaling during development of left-right asymmetry. This unique combination of activities suggests that syndecan-2 can function as a potential drug target for the development of multi-functional, anti-cancer therapeutics. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：152 / 156

页数：5

共 20 条

[1] Syndecans in tumor cell adhesion and signaling [J].