Pharmacogenomics in clinical practice and drug development

被引：73

作者：

Harper, Andrew R. ^{[1
,2
]}

Topol, Eric J. ^{[1
]}

机构：

[1] Scripps Res Inst & Scripps Hlth, Scripps Translat Sci Inst, La Jolla, CA USA

[2] Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

NATURE BIOTECHNOLOGY | 2012年 / 30卷 / 11期

关键词：

GENOME-WIDE ASSOCIATION; CHRONIC HEPATITIS-C; INFLUENCING ANTIHYPERTENSIVE RESPONSE; INDUCED LIVER-INJURY; GENETIC-VARIATION; MULTIPLE LOCI; IL28B; VARIANTS; GENOTYPE; THERAPY;

D O I：

10.1038/nbt.2424

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genome-wide association studies (GWAS) of responses to drugs, including clopidogrel, pegylated-interferon and carbamazepine, have led to the identification of specific patient subgroups that benefit from therapy. However, the identification and replication of common sequence variants that are associated with either efficacy or safety for most prescription medications at odds ratios (ORs) > 3.0 (equivalent to > 300% increased efficacy or safety) has yet to be translated to clinical practice. Although some of the studies have been completed, the results have not been incorporated into therapy, and a large number of commonly used medications have not been subject to proper pharmacogenomic analysis. Adoption of GWAS, exome or whole genome sequencing by drug development and treatment programs is the most striking near-term opportunity for improving the drug candidate pipeline and boosting the efficacy of medications already in use.

引用

页码：1117 / 1124

页数：8

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