Thymidine-Dependent Staphylococcus aureus Small-Colony Variants: Human Pathogens That Are Relevant Not Only in Cases of Cystic Fibrosis Lung Disease

被引：32

作者：

Besier, Silke ^{[1
]}

Zander, Johannes ^{[1
]}

Siegel, Ekkehard ^{[2
]}

Saum, Stephan H. ^{[3
]}

Hunfeld, Klaus-Peter ^{[1
]}

Ehrhart, Annabelle ^{[1
]}

Brade, Volker ^{[1
]}

Wichelhaus, Thomas A. ^{[1
]}

机构：

[1] Hosp Johann Wolfgang Goethe Univ, Inst Med Microbiol & Infect Control, D-60596 Frankfurt, Germany

[2] Hosp Johannes Gutenberg Univ, Inst Med Microbiol, Mainz, Germany

[3] Goethe Univ Frankfurt, Inst Mol Biosci, Frankfurt, Germany

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 11期

关键词：

D O I：

10.1128/JCM.01440-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.

引用

页码：3829 / 3832

页数：4

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