Preparation of bioactive porous HA/PCL composite scaffolds

被引：84

作者：

Zhao, J. ^{[1
]}

Guo, L. Y. ^{[1
]}

Yang, X. B. ^{[1
]}

Weng, J. ^{[1
]}

机构：

[1] SW Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2008年 / 255卷 / 05期

关键词：

Hydroxyapatite; Porous composite scaffold; polycaprolactone lining; Biomimetic; Apatite;

D O I：

10.1016/j.apsusc.2008.08.056

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Porous hydroxyapatite (HA) bioceramic scaffold has been widely attracted the attention to act as a three-dimensional (3D) template for cell adhesion, proliferation, differentiation and thus promoting bone and cartilage regeneration because of its osteoinduction. However, the porous bioceramic scaffold is fragile so that it is not suitable to be applied in clinic for bone repair or replacement. Therefore, it is significant to improve the mechanical property of porous HA bioceramics while the interconnected structure is maintained for tissue ingrowth in vivo. In the present research, a porous composite scaffold composed of HA scaffold and polycaprolactone (PCL) lining was fabricated by the method of polymer impregnating to produce HA scaffold coated with PCL lining. Subsequently, the composite scaffolds were deposited with biomimetic coating for improving the bioactivity. The HA/PCL composite scaffolds with improved mechanical property and bioactivity is expected to be a promising bone substitute in tissue engineering applications. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：2942 / 2946

页数：5

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