Synthesis of indolizine derivatives by the reaction of 2-(2′-pyridyl)-pyridinium ylides with ethylenic dipolarophiles

被引：30

作者：

Druta, II ^{[1
]}

Andrei, MA ^{[1
]}

Ganj, CI ^{[1
]}

Aburel, PS ^{[1
]}

机构：

[1] Al I Cuza Univ, Dept Organ Chem, Iasi 6600, Romania

来源：

TETRAHEDRON | 1999年 / 55卷 / 45期

关键词：

2,2 '-bipyridyl; 2-(2 '-pyridyl)-piridinium ylides; indolizines; cycloaddition reaction;

D O I：

10.1016/S0040-4020(99)00798-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-(2'-pyridyl)-pyridinium N-ylides with substituted ethylenes such as acrylonitrile and ethyl acrylate gave the corresponding tetrahydroindolizine derivatives in high yields. Tetrahydroindolizine derivatives were dehydrogenated by treating with tetrapyridinecobalt(II) bichromate [CoPy4(HCrO4)(2)] to give aromatic indolizines bearing cyano, aroyl, 2'-pyridyl, ester group at the different positions. Seventeen new indolizine derivatives were prepared. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：13063 / 13070

页数：8

共 20 条

[11]

PADWA A, 1984, 1 3 DIPOLAR CYCLOADD, V2, P277

[12] STUDIES ON HETEROAROMATICITY .52. SYNTHESES AND REACTIONS OF ALPHA-ACETYLENIC KETONES CONTAINING NITROFURAN RING [J].