Safety of low dose glucocorticoid treatment in rheumatoid arthritis:: published evidence and prospective trial data

被引：393

作者：

Da Silva, JAP ^{[1
]}

Jacobs, JWG

Kirwan, JR

Boers, M

Saag, KG

Inês, LBS

de Koning, EJP

Buttgereit, F

Cutolo, M

Capell, H

Rau, R

Bijlsma, JWJ

机构：

[1] Univ Hosp, P-3000075 Coimbra, Portugal

[2] Univ Utrecht, Med Ctr, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands

[3] Univ Bristol, Bristol Royal Infirm, Acad Rheumatol Unit, Bristol BS2 8HW, Avon, England

[4] Vrije Univ Amsterdam, Med Ctr, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands

[5] Univ Alabama Birmingham, Dept Clin Immunol & Rheumatol, Birmingham, AL USA

[6] Leiden Univ, Med Ctr, Dept Nephrol, Leiden, Netherlands

[7] Leiden Univ, Med Ctr, Dept Endocrinol, Leiden, Netherlands

[8] Charite Univ Med Berlin, Berlin, Germany

[9] Univ Genoa, Res Lab, I-16126 Genoa, Italy

[10] Univ Genoa, Dept Internal Med, Div Rheumatol, I-16126 Genoa, Italy

[11] Glasgow Royal Infirm, Ctr Rheumat Dis, Glasgow G4 0SF, Lanark, Scotland

[12] Evangel Fachkrankenhaus, Dept Rheumatol, Ratingen, Germany

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2006年 / 65卷 / 03期

关键词：

D O I：

10.1136/ard.2005.038638

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adverse effects of glucocorticoids have been abundantly reported. Published reports on low dose glucocorticoid treatment show that few of the commonly held beliefs about their incidence, prevalence, and impact are supported by clear scientific evidence. Safety data from recent randomised controlled clinical trials of low dose glucocorticoid treatment in RA suggest that adverse effects associated with this drug are modest, and often not statistically different from those of placebo.

引用

页码：285 / 293

页数：9

共 166 条

[61] A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo [J].