A four stranded β-sheet structure in a designed, synthetic polypeptide

被引:36
作者
Das, C
Raghothama, S
Balaram, P [1 ]
机构
[1] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India
[2] Indian Inst Sci, Sophisticated Instrumentat Facil, Bangalore 560012, Karnataka, India
关键词
D O I
10.1039/a902466b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A designed four stranded beta-sheet peptide has been constructed using three internal D-proline residues to nucleate beta-hairpin formation.
引用
收藏
页码:967 / 968
页数:2
相关论文
共 15 条
[1]   NATIVE-LIKE AND STRUCTURALLY CHARACTERIZED DESIGNED ALPHA-HELICAL BUNDLES [J].
BETZ, SF ;
BRYSON, JW ;
DEGRADO, WF .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1995, 5 (04) :457-463
[2]   PREDICTION OF PROTEIN CONFORMATION [J].
CHOU, PY ;
FASMAN, GD .
BIOCHEMISTRY, 1974, 13 (02) :222-245
[3]   A designed three stranded β-sheet peptide as a multiple β-hairpin model [J].
Das, C ;
Raghothama, S ;
Balaram, P .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (23) :5812-5813
[4]   β-hairpins in proteins revisited:: lessons for de novo design [J].
Gunasekaran, K ;
Ramakrishnan, C ;
Balaram, P .
PROTEIN ENGINEERING, 1997, 10 (10) :1131-1141
[5]   Torsion angle dynamics for NMR structure calculation with the new program DYANA [J].
Guntert, P ;
Mumenthaler, C ;
Wuthrich, K .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (01) :283-298
[6]   Solutions structure of α2D, a nativelike de novo designed protein [J].
Hill, RB ;
DeGrado, WF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (06) :1138-1145
[7]   Alternative conformations of amyloidogenic proteins govern their behavior [J].
Kelly, JW .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (01) :11-17
[8]   Design of a 20-amino acid, three-stranded β-sheet protein [J].
Kortemme, T ;
Ramírez-Alvarado, M ;
Serrano, L .
SCIENCE, 1998, 281 (5374) :253-256
[9]   A stable single-layer β-sheet without a hydrophobic core [J].
Pham, TN ;
Koide, A ;
Koide, S .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (02) :115-119
[10]  
Richardson J S, 1981, Adv Protein Chem, V34, P167, DOI 10.1016/S0065-3233(08)60520-3