Protein kinases as drug targets in trypanosomes and Leishmania

被引:166
作者
Naula, C
Parsons, M
Mottram, JC
机构
[1] Univ Glasgow, Wellcome Ctr Mol Parasitol, Anderson Coll, Glasgow G11 6NU, Lanark, Scotland
[2] Seattle Biomed Res Inst, Seattle, WA 98109 USA
[3] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2005年 / 1754卷 / 1-2期
基金
英国惠康基金;
关键词
protein kinase; cell cycle; chemotherapy; Trypanosoma; Leishmania; CYCLIN-DEPENDENT KINASE; HISTONE H1 KINASE; CELL-CYCLE; FLAGELLAR-LENGTH; MITOTIC CYCLIN; CHAGAS-DISEASE; PROCYCLIC FORM; BRUCEI; MEXICANA; CRUZI;
D O I
10.1016/j.bbapap.2005.08.018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protein kinases represent promising drug targets for a number of human and animal diseases. The recent completion of the sequenced genomes of three human-infective trypanosomatid protozoa, Leishmania major, Trypanosoma brucei and Trypanosoma cruzi, has allowed the kinome for each parasite to be defined as 179, 156 and 171 eukaryotic protein kinases respectively, that is about one third of the human complement. The analysis revealed that the trypanosomatids lack members of the receptor-linked or cytosolic tyrosine kinase families, but have an abundance of STE and CMGC family protein kinases likely to be involved in regulating cell cycle control, differentiation and response to stress during their complex life-cycles. In this review, we examine the prospects for exploiting differences between parasite and mammalian protein kinases to develop novel anti-parasitic chemotherapeutic agents. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:151 / 159
页数:9
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