Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral amino alcohol-based ligands

被引：90

作者：

Lu, G

Li, XS

Zhou, ZY

Chan, WL ^{[1
]}

Chan, ASC

机构：

[1] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0957-4166(01)00384-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of binaphthyl-derived amino alcohols were synthesized and used as catalytic ligands in the asymmetric alkynylation of aromatic aldehydes in the presence of a dialkylzinc reagent. The alkynylation of a variety of aromatic aldehydes gave the corresponding chiral propargylic alcohols in 61-93% e.e. (C) 2001 Published by Elsevier Science Ltd.

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页码：2147 / 2152

页数：6

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