Influence of circulating epinephrine and norepinephrine on insulin-like growth factor binding protein-1 in humans

被引:22
作者
FernqvistForbes, E [1 ]
Hilding, A [1 ]
Ekberg, K [1 ]
Brismar, K [1 ]
机构
[1] KAROLINSKA HOSP, DEPT MOL MED, ENDOCRINE & DIABET UNIT, S-17176 STOCKHOLM, SWEDEN
关键词
D O I
10.1210/jc.82.8.2677
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations. Healthy men received 0.3 nmol(.)kg(.)min Epi iv (n = 6), 0.5 nmol(.)kg(.)min Norepi iv (n = 7), or saline (n = 5) during 30 min. Arterial blood samples were obtained before, during, and 120 min after infusion. During the catecholamine infusion arterial Epi and Norepi plasma concentrations reached 6.35 +/- 0.53 and 15.65 +/- 2.71 nmol/L, respectively, which resulted in significant increases in glucose concentrations. When Epi was infused, IGFBP-1 increased from 45 +/- 6 mu g/L to 76 +/- 10 mu g/L (P < 0.05) 60 min after the infusion. Epi was also followed by increases in insulin, C-peptide, and glucagon. Norepi resulted in a slight increase in circulating IGFBP-1 (43 +/- 6 to 54 +/- 8 nmol/L, NS). The findings suggest that Epi, at plasma concentrations similar to those reached during physical stress, stimulates the production of IGFBP-1 in humans.
引用
收藏
页码:2677 / 2680
页数:4
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