Nitric oxide: considerations for the treatment of ischemic stroke

被引：110

作者：

Terpolilli, Nicole A. ^{[2
]}

Moskowitz, Michael A. ^{[3
]}

Plesnila, Nikolaus ^{[1
]}

机构：

[1] Univ Munich, Sch Med, Inst Stroke & Dementia Res, Munich, Germany

[2] Univ Munich, Sch Med, Dept Neurosurg, Munich, Germany

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Neurosci, Boston, MA USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2012年 / 32卷 / 07期

关键词：

acute stroke; experimental; focal ischemia; neuroprotection; nitric oxide; CEREBRAL-BLOOD-FLOW; HIGH-DENSITY-LIPOPROTEIN; COA REDUCTASE INHIBITOR; ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE AKT; RHO-KINASE; L-ARGININE; ARTERY OCCLUSION; RELAXING FACTOR; OBLIGATORY ROLE;

D O I：

10.1038/jcbfm.2012.12

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Some 40 years ago it was recognized by Furchgott and colleagues that the endothelium releases a vasodilator, endothelium-derived relaxing factor (EDRF). Later on, several groups identified EDRF to be a gas, nitric oxide (NO). Since then, NO was identified as one of the most versatile and unique molecules in animal and human biology. Nitric oxide mediates a plethora of physiological functions, for example, maintenance of vascular tone and inflammation. Apart from these physiological functions, NO is also involved in the pathophysiology of various disorders, specifically those in which regulation of blood flow and inflammation has a key role. The aim of the current review is to summarize the role of NO in cerebral ischemia, the most common cause of stroke. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 1332-1346; doi: 10.1038/jcbfm.2012.12; published online 15 February 2012

引用

页码：1332 / 1346

页数：15

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