Synergistic Effect of Histamine and TNF-α on Monocyte Adhesion to Vascular Endothelial Cells

被引：18

作者：

Chen, Chong ^{[1
]}

Khismatullin, Damir B. ^{[1
]}

机构：

[1] Tulane Univ, Lindy Boggs Ctr, Dept Biomed Engn, New Orleans, LA 70118 USA

来源：

INFLAMMATION | 2013年 / 36卷 / 02期

关键词：

histamine; TNF-alpha; monocyte; endothelium; cell adhesion; inflammation; allergy; atherosclerosis; P-SELECTIN; ALLERGIC REACTIONS; BLOOD HISTAMINE; ACTIVATION; ATHEROSCLEROSIS; RELEASE; FLOW; INFLAMMATION; MECHANISMS; EXPRESSION;

D O I：

10.1007/s10753-012-9548-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The histamine level is high during allergic attacks, and patients with allergy may have chronic inflammatory conditions at which tumor necrosis factor (TNF)-alpha is extensively released by macrophages. Here, in vitro static and microfluidic flow assays were conducted to investigate the combined influence of histamine and TNF-alpha on adhesion of monocytic THP-1 cells to human umbilical vein endothelial cells (HUVEC). In a static assay, histamine stimulation of TNF-alpha-activated HUVEC elevated the number of attached THP-1 cells. In a flow assay, the number of crawling and firmly adherent THP-1 cells was higher on TNF-alpha + histamine activated HUVEC than on HUVEC activated by TNF-alpha alone. This synergistic effect of histamine and TNF-alpha is caused by the increased endothelial surface expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. Since the exposure of TNF-alpha-activated endothelium to histamine favors monocyte recruitment, it may be a serious risk factor for atherosclerosis and other inflammatory disorders.

引用

页码：309 / 319

页数：11

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