Inhibition by MK-801 of morphine-induced conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice

被引:60
作者
Kim, HS
Jang, CG
Park, WK
机构
[1] Department of Pharmacology, College of Pharmacy, Chungbuk National University
关键词
MK-801; morphine; CPP; DA receptor supersensitivity;
D O I
10.1016/0091-3057(96)00078-0
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Intraperitoneal injection of morphine (5 mg/kg) in mice every other day for 8 days produced conditioned place preference (CPP). CPP effects were evaluated by assessing the difference in time spent in the drug-paired compartment and the saline-paired compartment of the place conditioning apparatus. The injection of a noncompetitive NMDA antagonist, MK-801 (0.05 and 0.1 mg/kg, IF), prior to and during morphine treatment in mice inhibited morphine-induced CPP. The development of postsynaptic dopamine (DA) receptor supersensitivity in mice displaying a morphine-induced CPP was evidenced by the enhanced response in ambulatory activity to the DA agonist, apomorphine (2 mg/kg). Mg-801 inhibited that development of postsynaptic DA receptor supersensitivity. MK-801 also inhibited apomorphine-induced climbing behavior, suggesting that MK-801 inhibits dopaminergic activation mediated via the NMDA receptor. These results suggest that the development of morphine-induced CPP may be associated with the development of postsynaptic DA receptor supersensitivity. The development of morphine-induced CPP and DA receptor supersensitivity may be closely related to NMDA receptor-mediated dopaminergic activity, because morphine-induced changes in sensitivity to apomorphine, as well as apomorphine induced climbing behavior in morphine treated mice, were both blocked by MK-801.
引用
收藏
页码:11 / 17
页数:7
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