Polymer-supported lipid shells, onions, and flowers

被引:69
作者
Bershteyn, Anna [1 ]
Chaparro, Jose [1 ]
Yau, Richard [1 ]
Kim, Mikyung [2 ]
Reinherz, Ellis [2 ]
Ferreira-Moita, Luis [3 ]
Irvine, Darrell J. [1 ]
机构
[1] MIT, Dept Mat Sci & Engn & Biol Engn, Cambridge, MA 02139 USA
[2] Dana Farber Canc Inst, Boston, MA 02115 USA
[3] Inst Mol Med, Cell Biol Immune Syst Unit, P-1649028 Lisbon, Portugal
关键词
D O I
10.1039/b804933e
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Phospholipid-enveloped biodegradable polymer microparticles and nanoparticles synthesized by an emulsion-solvent evaporation process were characterized by confocal and cryoelectron micros-copies to show that the lipid envelope exhibits two-dimensional fluidity and can be configured into 'shell', 'onion', or 'flower' nanostructures, depending on the quantity and composition of lipids employed in the synthesis.
引用
收藏
页码:1787 / 1791
页数:5
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