T cell receptor-mediated signs and signals governing T cell development

被引:42
作者
van Oers, NSC
机构
[1] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75235 USA
关键词
adaptor proteins; protein tyrosine kinases; signal transduction; T cell receptor;
D O I
10.1006/smim.1999.0179
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The developmental fate of T cells is largely controlled by the nature and success of signals mediated by the pre-T cell receptor (TCR) and TCR complexes. These intracellular signals are regulated by cascades of protein tyrosine phosphorylations initiated following ligand binding to the pre-TCR or TCR complexes. The phosphorylation cascades are primarily orchestrated by two distinct families of protein tyrosine Kinases (PTKs), the Src- and the Syk/ZAP-70-families. Germline gene targeting experiments, several human immunodeficiencies and somatic cell mutants have all contributed to our understanding of how these families of kinases coordinate their actions to promote signaling. Upon activation, the PTKs transmit their signals to a number of newly described adaptor proteins including LAT, SLP-76, and vav, among others. The folio-wing review combines results derived from different experimental strategies to examine the contributions of the PTKs and the adaptor molecules to pre-TCR and TCR signaling processes.
引用
收藏
页码:227 / 237
页数:11
相关论文
共 82 条
  • [1] A SIGNALING PATHWAY GOVERNING EARLY THYMOCYTE MATURATION
    ANDERSON, SJ
    PERLMUTTER, RM
    [J]. IMMUNOLOGY TODAY, 1995, 16 (02): : 99 - 105
  • [2] DEFECTIVE T-CELL RECEPTOR SIGNALING IN MICE LACKING THE THYMIC ISOFORM OF P59(FYN)
    APPLEBY, MW
    GROSS, JA
    COOKE, MP
    LEVIN, SD
    QIAN, X
    PERLMUTTER, RM
    [J]. CELL, 1992, 70 (05) : 751 - 763
  • [3] DEFECTIVE T-CELL RECEPTOR SIGNALING AND CD8(+) THYMIC SELECTION IN HUMANS LACKING ZAP-70 KINASE
    ARPAIA, E
    SHAHAR, M
    DADI, H
    COHEN, A
    ROIFMAN, CM
    [J]. CELL, 1994, 76 (05) : 947 - 958
  • [4] GENETIC AND MUTATIONAL ANALYSIS OF THE T-CELL ANTIGEN RECEPTOR
    ASHWELL, JD
    KLAUSNER, RD
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 : 139 - 167
  • [5] BLYTH KF, 1996, J EXP MED, V183, P1707
  • [6] NEW NOMENCLATURE FOR THE RETH MOTIF (OR ARH1/TAM/ARAM/YXXL)
    CAMBIER, JC
    DAERON, M
    FRIDMAN, W
    GERGELY, J
    KINET, JP
    KLAUSNER, R
    LYNCH, R
    MALISSEN, B
    PECHT, I
    REINHERZ, E
    RAVETCH, J
    RETH, M
    SAMELSON, L
    SANDOR, M
    SCHREIBER, A
    SEED, B
    TERHORST, C
    VANDEWINKEL, J
    WEISS, A
    [J]. IMMUNOLOGY TODAY, 1995, 16 (02): : 110 - 110
  • [7] T cell antigen receptor signal transduction pathways
    Cantrell, D
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 : 259 - 274
  • [8] ZAP-70 DEFICIENCY IN AN AUTOSOMAL RECESSIVE FORM OF SEVERE COMBINED IMMUNODEFICIENCY
    CHAN, AC
    KADLECEK, TA
    ELDER, ME
    FILIPOVICH, AH
    KUO, WL
    IWASHIMA, M
    PARSLOW, TG
    WEISS, A
    [J]. SCIENCE, 1994, 264 (5165) : 1599 - 1601
  • [9] THE ROLE OF PROTEIN-TYROSINE KINASES AND PROTEIN-TYROSINE PHOSPHATASES IN T-CELL ANTIGEN RECEPTOR SIGNAL-TRANSDUCTION
    CHAN, AC
    DESAI, DM
    WEISS, A
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 : 555 - 592
  • [10] ACTIVATION OF ZAP-70 KINASE-ACTIVITY BY PHOSPHORYLATION OF TYROSINE-493 IS REQUIRED FOR LYMPHOCYTE ANTIGEN RECEPTOR FUNCTION
    CHAN, AC
    DALTON, M
    JOHNSON, R
    KONG, GH
    WANG, T
    THOMA, R
    KUROSAKI, T
    [J]. EMBO JOURNAL, 1995, 14 (11) : 2499 - 2508