Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy

被引:53
作者
Hulme, C [1 ]
Ma, L [1 ]
Romano, J [1 ]
Morrissette, M [1 ]
机构
[1] Rhone Poulenc Rorer Cent Res, Dept New Leads Discovery, Collegeville, PA 19426 USA
关键词
D O I
10.1016/S0040-4039(99)01580-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable 'three-step-one-pot' procedure, utilizing a Ugi/de-Boc/cyclization (UDC) strategy. Transformations are carried out in excellent yield by condensation of N-Boc-alpha-amino-aldehydes and supporting Ugi reagents. The described protocol represents a highly attractive solution phase procedure for the rapid generation of this class of molecule. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7925 / 7928
页数:4
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