Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy

被引：53

作者：

Hulme, C ^{[1
]}

Ma, L ^{[1
]}

Romano, J ^{[1
]}

Morrissette, M ^{[1
]}

机构：

[1] Rhone Poulenc Rorer Cent Res, Dept New Leads Discovery, Collegeville, PA 19426 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(99)01580-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable 'three-step-one-pot' procedure, utilizing a Ugi/de-Boc/cyclization (UDC) strategy. Transformations are carried out in excellent yield by condensation of N-Boc-alpha-amino-aldehydes and supporting Ugi reagents. The described protocol represents a highly attractive solution phase procedure for the rapid generation of this class of molecule. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7925 / 7928

页数：4

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