Abietanes from Plectranthus grandidentatus and P-hereroensis against methicillin- and vancomycin-resistant bacteria

被引：60

作者：

Gaspar-Marques, C

Rijo, P

Simeoes, MF ^{[1
]}

Duarte, MA

Rodriguez, B

机构：

[1] Univ Lisbon, Fac Farm, CECF, Lisbon, Portugal

[2] Univ Lisbon, Fac Farm, Microbiol Lab, P-1699 Lisbon, Portugal

[3] CSIC, Inst Quim Organ, E-28006 Madrid, Spain

来源：

PHYTOMEDICINE | 2006年 / 13卷 / 04期

关键词：

Plectranthus sp; abietanes; antimicrobial; anti-MRSA activity; coleon U; royleanones;

D O I：

10.1016/j.phymed.2005.06.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active diterpenes were coleon U (1), 7 alpha-acetoxy-6 beta-hydroxyroyleanone (2) and horminone (3). Minimum inhibitory concentration (MIC) values ranging 0.98-15.63 mu g/ml were obtained for MRSA clinical strains, and MIC values of 15.63 and 31.25 mu g/ml were obtained for VRE clinical strains. Some structure-activity relationships are emphasized. (c) 2005 Elsevier GmbH. All rights reserved.

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页码：267 / 271

页数：5

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