Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines

被引：52

作者：

Marques, CG

Pedro, M

Simoes, MFA

Nascimento, MSJ

Pinto, MMM

Rodríguez, B

机构：

[1] Univ Lisbon, Fac Farm, CECF, P-1649019 Lisbon, Portugal

[2] Univ Porto, Fac Farm, Ctr Estudos Quim Organ, Oporto, Portugal

[3] CSIC, Inst Quim Organ, E-28006 Madrid, Spain

来源：

PLANTA MEDICA | 2002年 / 68卷 / 09期

关键词：

D O I：

10.1055/s-2002-34407

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gurke, were evaluated for their in vitro anti proliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines.

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收藏

页码：839 / 840

页数：2

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