Molecular mechanisms of defective eosinophil apoptosis in diseases associated with eosinophilia

被引：21

作者：

Simon, HU

机构：

[1] Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1997年 / 113卷 / 1-3期

关键词：

apoptosis; cytokines; eosinophils; fas; inflammation; signal transduction;

D O I：

10.1159/000237548

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis is a necessary process to maintain correct cell numbers in a multicellular organism. Defects in this process may contribute to the pathogenesis of a number of human diseases. We have suggested that inhibition of apoptosis in eosinophils by cytokines such as IL-5 and GM-CSF may play an important role in the pathogenesis of allergic disorders. Here, we review our recent progress in understanding the processes regulating eosinophil apoptosis.

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收藏

页码：206 / 208

页数：3

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